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Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice
CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang
《医学前沿(英文)》 2008年 第2卷 第2期 页码 154-165 doi: 10.1007/s11684-008-0029-7
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
《医学前沿(英文)》 2021年 第15卷 第2期 页码 292-301 doi: 10.1007/s11684-020-0806-5
关键词: bioactive hyaluronan lipopolysaccharide inflammatory cytokines TLR4 human macrophages
巨噬细胞在器官移植急性排斥反应中的双重作用 Review
谭亮, 郭易难, 冯畅, 侯仰潇, 谢续标, 赵勇
《工程(英文)》 2022年 第10卷 第3期 页码 21-29 doi: 10.1016/j.eng.2021.10.015
天然免疫细胞在移植免疫反应中发挥着重要作用。巨噬细胞是重要的天然免疫细胞;在发生排斥反应的同种异基因移植器官中,巨噬细胞也是浸润的众多免疫细胞之一。巨噬细胞的浸润与器官移植的短期和长期效果呈负相关。在功能方面,巨噬细胞具有异质性和可塑性。在器官移植排斥反应中,巨噬细胞可以为适应性免疫提呈同种异基因抗原以及提供共刺激信号和细胞因子,也可以直接损伤移植器官。此外,一些具有免疫调节功能的巨噬细胞亚群,可以通过抑制排斥反应和促进免疫耐受来保护移植器官。尽管目前研究人员已认识到巨噬细胞在移植器官损伤过程中的潜在作用,但他们对巨噬细胞在移植排斥反应中的不同作用关注不够。为此,本文就巨噬细胞在急性移植免疫反应中的独特作用以及免疫抑制剂对巨噬细胞的影响进行了综述和讨论。通过分析发现,对于巨噬细胞在移植免疫中的作用的相关研究中,应更多地关注其复杂性和关键功能,并应更多地致力于开发针对巨噬细胞的免疫抑制药物,并使之有利于提高移植器官的长期存活率和移植免疫耐受的建立。
Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages
《医学前沿(英文)》 2023年 第17卷 第2期 页码 304-316 doi: 10.1007/s11684-022-0964-8
关键词: macrophage glycoproteome glycopeptides N-glycan structures PD-L1
SWIR Fluorescence Imaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Article
Mo Chen, Yuzhou Chen, Sijia Feng, Shixian Dong, Luyi Sun, Huizhu Li, Fuchun Chen, Nguyen Thi Kim Thanh, Yunxia Li, Shiyi Chen, You Wang, Jun Chen
《工程(英文)》 doi: 10.1016/j.eng.2023.05.010
Skeletal muscle has a robust regeneration ability that is impaired by severe injury, disease, and aging, resulting in a decline in skeletal muscle function. Therefore, improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related disorders. Owing to their significant role in tissue regeneration, implantation of M2 macrophages (M2Mø) has great potential for improving skeletal muscle regeneration. Here, we present a short-wave infrared (SWIR) fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2Mø transplantation. SWIR fluorescence imaging was employed to track implanted M2Mø in the injured skeletal muscle of mouse models. It is found that the implanted M2Mø accumulated at the injury site for two weeks. Then, SWIR fluorescence imaging of blood vessels showed that M2Mø implantation could improve the relative perfusion ratio on day 5 (1.09 ± 0.09 vs 0.85 ± 0.05; p = 0.01) and day 9 (1.38 ± 0.16 vs 0.95 ± 0.03; p = 0.01) post-injury, as well as augment the degree of skeletal muscle regeneration on day 13 post-injury. Finally, multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle regeneration. These results provide more in vivo details about M2Mø in skeletal muscle regeneration and confirm that M2Mø could promote angiogenesis and improve the degree of skeletal muscle repair, which will guide the research and development of M2Mø implantation to improve skeletal muscle regeneration.
关键词: In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration
Challenges of human–machine collaboration in risky decision-making
《工程管理前沿(英文)》 2022年 第9卷 第1期 页码 89-103 doi: 10.1007/s42524-021-0182-0
关键词: human–machine collaboration risky decision-making human–machine team and interaction task allocation human–machine relationship
Zooming in and out of ferroptosis in human disease
《医学前沿(英文)》 2023年 第17卷 第2期 页码 173-206 doi: 10.1007/s11684-023-0992-z
关键词: ferroptosis human disease iron metabolism lipid peroxidation antioxidation
Dan DAI, Jing LIU
《能源前沿(英文)》 2012年 第6卷 第3期 页码 210-226 doi: 10.1007/s11708-012-0200-3
关键词: human energy harvesting human-powered transportation human-powered home appliances human-powered grid (HPG) human-powered charger (HPC) human-powered storage (HPS) biofuel
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 20-29 doi: 10.1007/s11684-014-0371-x
Ischemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique “immunosuppressive and immunoprivilege” property, hUC-MSCs are advised to be an important candidate for allogeneic cell treatment. Nevertheless, most of the treatments are still at primary stage and not clinically feasible at the current time. Several uncertain problems, such as culture conditions, allograft rejection, and potential tumorigenicity, are the choke points in this cellular therapy. More preclinical researches and clinical studies are needed before hUC-MSCs implantation can be used as a routinely applied clinical therapy.
关键词: cellular therapy transplantation human umbilical cord mesenchymal stem cells ischemic stroke
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 480-489 doi: 10.1007/s11684-017-0594-8
Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
关键词: human immunodeficiency virus type I superinfection incidence immune response
An experimental analysis of human straight walking
Tao LI, Marco CECCARELLI
《机械工程前沿(英文)》 2013年 第8卷 第1期 页码 95-103 doi: 10.1007/s11465-013-0357-4
In this paper, an experimental analysis of human straight walking has been presented. Experiments on human walking were carried out by using Cassino tracking system which is a passive cable-based measuring system. This system is adopted because it is capable of both pose and wrench measurements with fairly simple monitoring of operation. By using experimental results, trajectories of a human limb extremity and its posture have been analyzed; forces that are exerted against cables by the limb of a person under test have been measured by force sensors as well. Furthermore, by using experimental tests, modeling and characterization of the human straight walking gait have been proposed.
关键词: human locomotion walking gait characterization humanoid robot biped robot
《环境科学与工程前沿(英文)》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1541-8
● Perfluorooctanesulfonic acid and perfluorooctanoic acid highest in human milk.
关键词: Human biomonitoring Human breast milk LC-MS/MS analysis Lifestyle parameters
Glorious Missions Assigned by the Human History
Jian Song
《工程管理前沿(英文)》 2014年 第1卷 第1期 页码 1-1 doi: 10.15302/J-FEM-2014001
An experimental characterization of human torso motion
Daniele CAFOLLA,I-Ming CHEN,Marco CECCARELLI
《机械工程前沿(英文)》 2015年 第10卷 第4期 页码 311-325 doi: 10.1007/s11465-015-0352-z
The torso plays an important role in the human-like operation of humanoids. In this paper, a method is proposed to analyze the behavior of the human torso by using inertial and magnetic sensing tools. Experiments are conducted to characterize the motion performance of the human torso during daily routine operations. Furthermore, the forces acting on the human body during these operations are evaluated to design and validate the performance of a humanoid robot.
关键词: experimental biomechanics human torso analysis inertial sensor characterization
《环境科学与工程前沿(英文)》 2021年 第15卷 第3期 doi: 10.1007/s11783-020-1356-4
•Bacterial concentrations from eight stages were 104–105copies/m3.
关键词: Size distribution Airborne bacteria Biological diversity Human pathogenic bacteria Composting plants
标题 作者 时间 类型 操作
Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice
CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang
期刊论文
Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the Toll-like receptor 4 signaling pathway
Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang
期刊论文
Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages
期刊论文
SWIR Fluorescence Imaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal
Mo Chen, Yuzhou Chen, Sijia Feng, Shixian Dong, Luyi Sun, Huizhu Li, Fuchun Chen, Nguyen Thi Kim Thanh, Yunxia Li, Shiyi Chen, You Wang, Jun Chen
期刊论文
Tackling global electricity shortage through human power: Technical opportunities from direct or indirectutilizations of the pervasive and green human energy
Dan DAI, Jing LIU
期刊论文
Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges
null
期刊论文
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
期刊论文
Perfluoroalkane acids in human milk under the global monitoring plan of the Stockholm Convention on Persistent
期刊论文
An experimental characterization of human torso motion
Daniele CAFOLLA,I-Ming CHEN,Marco CECCARELLI
期刊论文